Dichlorobenzyl chloride → 6-bromo-1-(2,3-dichlorobenzyl)-3-methyl-1H-indazole

HRID 2199975Notes

Reaction equation

HRID 2199975 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[Cl:12][C:13]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Cl.C(N1C2C(=CC=C(C(O)=O)C=2)C=C1)C1C=CC=CC=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][N:8]2[CH2:15][C:14]2[CH:17]=[CH:18][CH:19]=[C:20]([Cl:21])[C:13]=2[Cl:12])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 76790Dichlorobenzyl chlorideHCID 179478751-Benzyl-1H-indole-6-carboxylic acidHCID 178434209HCID 178434209, compound

Product 1

HCID 681842806-bromo-1-(2,3-dichlorobenzyl)-3-methyl-1H-indazoleYield 85.5%

Procedure

The titled compound (228 mg) as a white solid was prepared from the 6-bromo-3-methyl-1H-indazole (152 mg) obtained with the method described in the document (JP 2009-528363 W) and 2,3-dichlorobenzyl chloride (215 mg) according to the method of the process (1) of Example 66.

Workup

  1. customobtained with the method

Sources & evidence

ORD record
ord-fb2f1b9f1a17469db8243d9fb3caa2ae
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

Loading…