2,4,6-Trimethylbenzyl chloride → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199982Notes

Reaction equation

HRID 2199982 reaction equation
[CH3:1][C:2]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:3]=1[CH2:4]Cl.Cl[C:13]1[CH:33]=[CH:32][CH:31]=[C:30](C)[C:14]=1[CH2:15][N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:23]=2)[C:18]([CH3:29])=[N:17]1>>[CH3:29][C:18]1[C:19]2[C:24](=[CH:23][C:22]([CH2:25][C:26]([OH:28])=[O:27])=[CH:21][CH:20]=2)[N:16]([CH2:4][C:3]2[C:2]([CH3:1])=[CH:9][C:8]([CH3:10])=[CH:7][C:6]=2[CH3:11])[N:17]=1.[CH2:15]([N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:23]=2)[CH:18]=[CH:29]1)[C:14]1[CH:13]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 741082,4,6-Trimethylbenzyl chlorideHCID 60152152HCID 60152152, compound

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184447HCID 68184447, compound

Procedure

The titled compound (10.3 mg) as a white solid was prepared from the compound [102-4] obtained in the process (4) of Example 102 (21.2 mg) and 2,4,6-trimethylbenzyl chloride according to the method of the process (5) of Example 102.

Sources & evidence

ORD record
ord-a7f3f0121ce14779b471f1e54f109225
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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