3-Iodophenol → 3-(5-Amino-3-methyl-pyrazol-1-yl)-phenol

HRID 2200027Notes

Reaction equation

I[C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C[C@H]1CCC[C@@H](C)N1C1N2C=C(O[C@H]3C4C(=CC=CC=4)[C@@H](NC(=O)[NH:39][C:40]4[N:44](C5C=NN(CCOS(C)(=O)=O)C=5)[N:43]=[C:42]([CH:57](C)C)[CH:41]=4)CC3)C=CC2=NN=1>>[NH2:39][C:40]1[N:44]([C:2]2[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=2)[N:43]=[C:42]([CH3:57])[CH:41]=1

Participants

Reactant 2

HCID 122723-Iodophenol

HCID 117728990HCID 117728990, compound

Product 1

HCID 214324393-(5-Amino-3-methyl-pyrazol-1-yl)-phenol

Procedure

The title compound was prepared starting from 5-methyl-2H-amino pyrazol (500 mg, 5.1 mmol) and 3-iodo-phenol (1.25 g, 5.7 mmol) by using an analogous procedure to that described for Intermediate A step b. LCMS (Method 3): Rt 0.99 min, m/z=190 [MH+].

Sources & evidence

ORD record: ord-2897bb010d7c43e88afe5b40e9b965c2
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09359354B2

Reaction notes

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