反应详情

A solution of N-(1-(2-(1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yloxy)ethyl)pyrrolidin-3-yl)acetamide (0.1 g, 0.25 mmol) in water (2 ml) and 6N aqueous solution of HCl (2 ml) was refluxed for 5 hrs. The mixture was basified with 20% aqueous solution of NaOH and extracted with dichloromethane. The combined organic solutions was washed with water, dried over Na2SO4, filtered and evaporated to dryness yielding 80 mg of 1-{2-[1-(3,4-Dichlorophenyl)-5-methyl-1H-pyrazol-3-yloxy]ethyl}pyrrolidin-3-amine as an oil

1. extractionextracted with dichloromethane
2. washThe combined organic solutions was washed with water
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customevaporated to dryness