反应详情

A suspension of 0.330 g (2.0 mmol) of 2,6-dichloro-pyrazine 4-oxide in 0.485 g (4.0 mmol) of phenethylamine was allowed to stir under reflux for 10 min. pCooled water was added and the mixture extracted with dichloromethane, dried over sodium sulfate and evaporated to dryness. pThe residue obtained was purified by chromatography on silica gel eluting with a mixture of dichloromethane/methanol/diethylamine in the proportions 97/3/0.3 to give after trituration with diethyl ether 0.370 g (74%) of pure product as a grey solid.

1. temperatureunder reflux for 10 min.
2. additionwas added
3. extractionthe mixture extracted with dichloromethane
4. dry with materialdried over sodium sulfate
5. customevaporated to dryness
6. custompThe residue obtained
7. customwas purified by chromatography on silica gel eluting with a mixture of dichloromethane/methanol/diethylamine in the proportions 97/3/0.3
8. customto give after trituration with diethyl ether 0.370 g (74%) of pure product as a grey solid