HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-[[3-nitro-5-(trifluoromethyl)phenyl]methyl]piperazine → 3-((4-Methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-[[3-nitro-5-(trifluoromethyl)phenyl]methyl]piperazine | HCID 58902366 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-((4-Methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)aniline | HCID 23155052 | 100% |
Reaction Steps
Add Pd/C (10%, 200 mg) to the solution of 1-methyl-4-(3-nitro-5-(trifluoromethyl)benzyl)piperazine (812 mg, 2.68 mmol) in methanol (15 mL), flush with H2, stir under hydrogen atmosphere for 16 hrs at room temperature. Filter and concentrate the filtrate to give the crude product (732 mg, 100%). MS: (M+1): 273.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-b5973325894f445c9038746304f113c1 |
| Source note | uspto-grants-2016_06 |