3-ethoxy-N'-hydroxypropanimidamide → {3-[3-(2-Ethoxyethyl)-1,2,4-oxadiazol-5-yl]-5-(4-ethylphenyl)piperidin-1-yl}(thiomorpholin-4-yl)methanone

HRID 220015Notes

Reaction equation

HRID 220015 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][S:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23]([OH:25])=O)[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[CH2:26]([O:28][CH2:29][CH2:30][C:31](=[N:33]O)[NH2:32])[CH3:27]>>[CH2:26]([O:28][CH2:29][CH2:30][C:31]1[N:33]=[C:23]([CH:11]2[CH2:10][CH:9]([C:6]3[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=3)[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][S:20][CH2:19][CH2:18]3)=[O:16])[CH2:12]2)[O:25][N:32]=1)[CH3:27]

Participants

3

Reactant 2

HCID 50443873-ethoxy-N'-hydroxypropanimidamideHCID 581164645-(4-Ethylphenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid

Product 1

HCID 59606585{3-[3-(2-Ethoxyethyl)-1,2,4-oxadiazol-5-yl]-5-(4-ethylphenyl)piperidin-1-yl}(thiomorpholin-4-yl)methanone

Procedure

According to General Method 6A, 600 mg (1.655 mmol) of the compound from Example 7A and 355 mg (approx. 2.152 mmol) of 3-Ethoxy-N′-hydroxypropanimidamide were reacted Yield: 389 mg (49% of theory)

Workup

  1. customwere reacted Yield: 389 mg (49% of theory)

Sources & evidence

ORD record
ord-db1206c9c08d4cf8822433fd66e7d0e3
Source dataset
uspto-grants-2012_06
Patent number
US08202862B2

Reaction notes

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