HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 90020640, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-Bromo-3-nitro-5-(trifluoromethyl)benzene | HCID 7015411 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 90020640 | HCID 90020640 | 50% |
Reaction Steps
Dissolve 1-bromo-3-nitro-5-(trifluoromethyl)benzene (270 mg, 1 mmol) and DIEA (258 mg, 2 mmol) in DMF (5 mL), add morpholine (174 mg, 2 mmol). Stir the reaction at 120° C. overnight. Cool to room temperature; remove the volatiles under reduced pressure to give a crude residue. Purification of the residue by chromatography (silica gel, EtOAc:PE=1:5) affords the product (138 mg, 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359338B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-6787e43971da4c27836aeeb984848e1a |
| Source note | uspto-grants-2016_06 |