反应详情

Dissolve 1-bromo-3-nitro-5-(trifluoromethyl)benzene (270 mg, 1 mmol) and DIEA (258 mg, 2 mmol) in DMF (5 mL), add morpholine (174 mg, 2 mmol). Stir the reaction at 120° C. overnight. Cool to room temperature; remove the volatiles under reduced pressure to give a crude residue. Purification of the residue by chromatography (silica gel, EtOAc:PE=1:5) affords the product (138 mg, 50%).

1. customthe reaction at 120° C. overnight
2. customremove the volatiles under reduced pressure
3. customto give a crude residue
4. customPurification of the residue by chromatography (silica gel, EtOAc:PE=1:5)