Thionyl Chloride → 2-Chloropteridine

HRID 2200209Notes

Reaction equation

[N:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][N:9]=2)[C:4](=O)[NH:3][CH:2]=1.P(Cl)(Cl)([Cl:14])=O.S(Cl)(Cl)=O>>[Cl:14][C:2]1[N:3]=[CH:4][C:5]2[C:10](=[N:9][CH:8]=[CH:7][N:6]=2)[N:1]=1

Participants

Reactant 3

HCID 24386Thionyl Chloride

HCID 24813Phosphorus oxychloride

HCID 135460266Pteridin-4-ol

Product 1

HCID 6405372-Chloropteridine

Procedure

Reaction of pteridin-4(3H)-one IV′ with chlorinating agents such as phosphorous oxychloride or thionyl chloride affords chloro-pteridine V′. Suitable solvent for this reaction includes methylene chloride chloroform or toluene.

Sources & evidence

ORD record: ord-400149840379429dafc287d2fdd67a19
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09359361B2

Reaction notes

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