Ammonia → 5-Nitropyrimidin-2-amine

HRID 2200211Notes

Reaction equation

HRID 2200211 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[NH3:12]>>[NH2:12][C:4]1[N:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[CH:2][N:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 203124,6-Dichloro-5-nitropyrimidine

Product 1

HCID 764905-Nitropyrimidin-2-amine

Procedure

Reaction of 4,6-dichloro-5-nitropyrimidine XX′ with nucleophile NH3 and R7LYH affords amino-5-nitropyrimidine XXI′. Suitable solvents for this reaction include ethanol, methylene chloride, acetonitrile, and tetrahydrofuran.

Sources & evidence

ORD record
ord-1ab45e66025a4bd4bf66ef6b5e4c7e94
Source dataset
uspto-grants-2016_06
Patent number
US09359361B2

Reaction notes

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