HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-Nitropyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| Product | 5-Nitropyrimidin-2-amine | HCID 76490 | — |
Reaction Steps
Reaction of 4,6-dichloro-5-nitropyrimidine XX′ with nucleophile NH3 and R7LYH affords amino-5-nitropyrimidine XXI′. Suitable solvents for this reaction include ethanol, methylene chloride, acetonitrile, and tetrahydrofuran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359361B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-1ab45e66025a4bd4bf66ef6b5e4c7e94 |
| Source note | uspto-grants-2016_06 |