HCID 68310759, compound → HCID 68310070, compound

HRID 2200330Notes

Reaction equation

HRID 2200330 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][O:13][C@H:12]([C:15]([NH2:17])=[O:16])[CH2:11][CH2:10]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[NH2:8][C@H:9]1[CH2:14][O:13][C@H:12]([C:15]([NH2:17])=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 68310759HCID 68310759, compound

Product 1

HCID 68310070HCID 68310070, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

The compound (490 mg, 1.51 mmol) obtained in Step 2 above was dissolved in ethanol (10 ml), 20% palladium hydroxide (100 mg) was added and the resulting mixture was stirred at room temperature for 16 hours under a hydrogen atmosphere. The catalyst was removed by filtration through celite, then the solvent in the filtrate was evaporated under reduced pressure and the residue was dried to give 215 mg (99%) of the title compound as a solid.

Workup

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent in the filtrate was evaporated under reduced pressure
  3. customthe residue was dried

Sources & evidence

ORD record
ord-a33d5480f7b2483aabaa7b74fee0b974
Source dataset
uspto-grants-2016_06
Patent number
US09359368B2

Reaction notes

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