Hydrochloric Acid → HCID 67085022, compound

HRID 2200355Notes

Reaction equation

HRID 2200355 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C:9]2=[O:21])=[CH:4][CH:3]=1.[ClH:22].O1CCOCC1>ClCCl>[ClH:22].[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][C:9]2=[O:21])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67085032HCID 67085032, compound

Product 1

HCID 67085022HCID 67085022, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

To the solution of tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate (2 g, 6.80 mmol) in dichloromethane (5 ml) was added slowly hydrogenchloride in 1,4-dioxane (16.99 ml, 68.0 mmol) at 0° C. and reaction was stirred for 3 h at 25° C. After completion of the reaction, the solvent was evaporated under reduced pressure to obtained salt was triturated with diethyl ether (2×10 ml) decanted it and dried to give 1-(4-fluorophenyl)piperazin-2-one hydrochloride (1.2 g, 5.20 mmol, 77%)

Workup

  1. customreaction
  2. customAfter completion of the reaction
  3. customthe solvent was evaporated under reduced pressure
  4. customto obtained salt
  5. customwas triturated with diethyl ether (2×10 ml)
  6. customdecanted it
  7. customdried

Sources & evidence

ORD record
ord-71b91402ee504283ad7d46e1366f94ee
Source dataset
uspto-grants-2016_06
Patent number
US09359367B2

Reaction notes

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