Hydrochloric Acid → HCID 89924383, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl 4-(3-cyanopropyl)-3-methylpiperazine-1-carboxylate (1.3 g, 4.86 mmol) in diethyl ether (10 ml) was added hydrochloric acid (2 molar in ether, 10 ml, 20.00 mmol) at 0° C. The reaction mixture was stirred at room temperature for 5 h. Progress of the reaction was monitored by TLC. After completion of the reaction, the solvent was evaporated under reduced pressure and triturated with diethyl ether to yield the title compound 4-(2-methylpiperazin-1-yl)butanenitrile hydrochloride (1 g, 4.91 mmol, 24.54% yield)

Provenance & Evidence