Hydrochloric Acid → HCID 89924383, compound

HRID 2200363Notes

Reaction equation

HRID 2200363 reaction equation
[C:1]([CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH:7]1[CH3:19])#[N:2].[ClH:20]>C(OCC)C>[ClH:20].[CH3:19][CH:7]1[CH2:8][NH:9][CH2:10][CH2:11][N:6]1[CH2:5][CH2:4][CH2:3][C:1]#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56785630HCID 56785630, compound

Product 1

HCID 89924383HCID 89924383, compoundYield 101%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a stirred solution of tert-butyl 4-(3-cyanopropyl)-3-methylpiperazine-1-carboxylate (1.3 g, 4.86 mmol) in diethyl ether (10 ml) was added hydrochloric acid (2 molar in ether, 10 ml, 20.00 mmol) at 0° C. The reaction mixture was stirred at room temperature for 5 h. Progress of the reaction was monitored by TLC. After completion of the reaction, the solvent was evaporated under reduced pressure and triturated with diethyl ether to yield the title compound 4-(2-methylpiperazin-1-yl)butanenitrile hydrochloride (1 g, 4.91 mmol, 24.54% yield)

Workup

  1. customAfter completion of the reaction
  2. customthe solvent was evaporated under reduced pressure
  3. customtriturated with diethyl ether

Sources & evidence

ORD record
ord-e54db7f3d86f4a9d8625910e423ac4ea
Source dataset
uspto-grants-2016_06
Patent number
US09359367B2

Reaction notes

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