反应详情

温度

110 °C

(1R,3S)-methyl 3-aminocyclopentanecarboxylate hydrochloride (1.5 g, 8.35 mmol), 4-chloro-N,N-bis(2-chloroethyl)aniline (2.32 g, 9.18 mmol), sodium hydrogencarbonate (4.91 g, 58.4 mmol), and potassium iodide (0.14 g, 0.83 mmol) were suspended in n-butanol (50 mL). The reaction mixture was stirred at 110° C. for overnight. Upon completion, the reaction mixture was evaporated under vacuo. The resulting crude residue was purified by column chromatography using ethyl acetate in hexane as eluent to obtain (1R,3S)-methyl 3-(4-(4-chlorophenyl)piperazin-1-yl)cyclopentanecarboxylate (1.5 g, 55.6%).

1. customUpon completion, the reaction mixture was evaporated under vacuo
2. customThe resulting crude residue was purified by column chromatography