HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Nitrophenyl)pyridine → 4-(Pyridin-4-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Nitrophenyl)pyridine | HCID 259219 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Pyridin-4-yl)aniline | HCID 1512654 | 90.5% |
Reaction Steps
A mixture of 4-(4-nitrophenyl)pyridine (274 mg, 1.37 mmol) and Pd—C (10%, 80 mg) in MeOH (10 mL) was hydrogenated under balloon H2 for 20 h. The mixture was then filtered through celite. The filtrate was concentrated in vacuo to give 4-(pyridin-4-yl)aniline as a solid (211 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359308B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-7a25cde2b5b54a6f9767270dfdca7728 |
| Source note | uspto-grants-2016_06 |