HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-2-amino-3-(thiophen-2-yl)propanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-tert-butyl 1-amino-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate | HCID 67776928 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-2-amino-3-(thiophen-2-yl)propanamide hydrochloride | HCID 86685590 | — |
Reaction Steps
The solid (R)-tert-butyl 1-amino-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate (448 mg) was dissolved in dioxane (4 mL), aq. 6N HCl (5 mL) was added. After being stirred at room temperature for 1 h, the mixture was concentrated in vacuo to give (R)-2-amino-3-(thiophen-2-yl)propanamide hydrochloride as a solid (337 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359308B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-9c81fa897ecb468ebe3238a0e56cb207 |
| Source note | uspto-grants-2016_06 |