Hydrochloric Acid → (R)-2-amino-3-(thiophen-2-yl)propanamide hydrochloride

HRID 2200470Notes

Reaction equation

HRID 2200470 reaction equation
[NH2:1][C:2](=[O:18])[C@H:3]([NH:10]C(=O)OC(C)(C)C)[CH2:4][C:5]1[S:6][CH:7]=[CH:8][CH:9]=1.[ClH:19]>O1CCOCC1>[ClH:19].[NH2:10][C@H:3]([CH2:4][C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)[C:2]([NH2:1])=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67776928(R)-tert-butyl 1-amino-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate

Product 1

HCID 86685590(R)-2-amino-3-(thiophen-2-yl)propanamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The solid (R)-tert-butyl 1-amino-1-oxo-3-(thiophen-2-yl)propan-2-ylcarbamate (448 mg) was dissolved in dioxane (4 mL), aq. 6N HCl (5 mL) was added. After being stirred at room temperature for 1 h, the mixture was concentrated in vacuo to give (R)-2-amino-3-(thiophen-2-yl)propanamide hydrochloride as a solid (337 mg).

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-9c81fa897ecb468ebe3238a0e56cb207
Source dataset
uspto-grants-2016_06
Patent number
US09359308B2

Reaction notes

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