HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-2-Amino-2-phenylacetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate | HCID 10944841 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-2-Amino-2-phenylacetamide hydrochloride | HCID 16216957 | — |
Reaction Steps
The solid (R)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate (446 mg) was dissolved in dioxane (5 mL), aq. 6N HCl (8 mL) was added. After being stirred at room temperature for 20 h, the mixture was concentrated in vacuo to give (R)-2-amino-2-phenylacetamide hydrochloride as a solid (329 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359308B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-fbf2fc100d534242bc63d00888a5aa03 |
| Source note | uspto-grants-2016_06 |