Hydrochloric Acid → (R)-2-Amino-2-phenylacetamide hydrochloride

HRID 2200475Notes

Reaction equation

HRID 2200475 reaction equation
[NH2:1][C:2](=[O:18])[C@H:3]([NH:10]C(=O)OC(C)(C)C)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:19]>O1CCOCC1>[ClH:19].[NH2:10][C@H:3]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:2]([NH2:1])=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10944841(R)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate

Product 1

HCID 16216957(R)-2-Amino-2-phenylacetamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The solid (R)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate (446 mg) was dissolved in dioxane (5 mL), aq. 6N HCl (8 mL) was added. After being stirred at room temperature for 20 h, the mixture was concentrated in vacuo to give (R)-2-amino-2-phenylacetamide hydrochloride as a solid (329 mg).

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-fbf2fc100d534242bc63d00888a5aa03
Source dataset
uspto-grants-2016_06
Patent number
US09359308B2

Reaction notes

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