HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 86685606, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (R)-2-(5-cyano-6-(m-tolylamino)pyrazin-2-ylamino)-4-methylpentanamide | HCID 86685605 | — |
| Catalyst | Hydrogen Peroxide | HCID 784 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86685606 | HCID 86685606 | — |
Reaction Steps
To a mixture of (R)-2-(5-cyano-6-(m-tolylamino)pyrazin-2-ylamino)-4-methylpentanamide in methanol (1 ml) was added K2CO3 (excess)) and H2O2 (50%, a few drops). After completion, it was concentrated and purified by preparative HPLC to give (R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(m-tolylamino)pyrazine-2-carboxamide (6 mg). MS found for C18H24N6O2 as (M+H)+357.3, UV: λ=253.4, 304.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359308B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-f04f8270023a4ef5ad9af7cf7df1d0df |
| Source note | uspto-grants-2016_06 |