Potassium Carbonate → HCID 86685606, compound

HRID 2200489Notes

Reaction equation

HRID 2200489 reaction equation
[C:1]([C:3]1[N:4]=[CH:5][C:6]([NH:17][C@H:18]([CH2:22][CH:23]([CH3:25])[CH3:24])[C:19]([NH2:21])=[O:20])=[N:7][C:8]=1[NH:9][C:10]1[CH:11]=[C:12]([CH3:16])[CH:13]=[CH:14][CH:15]=1)#[N:2].C([O-])([O-])=[O:27].[K+].[K+]>CO.OO>[NH2:21][C:19](=[O:20])[C@H:18]([NH:17][C:6]1[N:7]=[C:8]([NH:9][C:10]2[CH:11]=[C:12]([CH3:16])[CH:13]=[CH:14][CH:15]=2)[C:3]([C:1]([NH2:2])=[O:27])=[N:4][CH:5]=1)[CH2:22][CH:23]([CH3:25])[CH3:24]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86685605HCID 86685605, compound

Product 1

HCID 86685606HCID 86685606, compound

Reagents, catalysts & solvents 2

HCID 784Hydrogen PeroxideCatalystHCID 887MethanolSolvent

Procedure

To a mixture of (R)-2-(5-cyano-6-(m-tolylamino)pyrazin-2-ylamino)-4-methylpentanamide in methanol (1 ml) was added K2CO3 (excess)) and H2O2 (50%, a few drops). After completion, it was concentrated and purified by preparative HPLC to give (R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(m-tolylamino)pyrazine-2-carboxamide (6 mg). MS found for C18H24N6O2 as (M+H)+357.3, UV: λ=253.4, 304.5.

Workup

  1. concentrationAfter completion, it was concentrated
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-f04f8270023a4ef5ad9af7cf7df1d0df
Source dataset
uspto-grants-2016_06
Patent number
US09359308B2

Reaction notes

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