反应详情

A solution of 45.0 mg (0.083 mmol, purity 72%) of the compound from Example 60A in ethanol (10.0 ml) was admixed with 69 μl (15 mg, 0.42 mmol) of concentrated hydrochloric acid. Subsequently, the mixture was stirred under reflux for 24 h, and the reaction solution was diluted with water and washed with diethyl ether. The aqueous phase was alkalized and extracted with dichloromethane. The organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 36.3 mg (87% of theory, purity 70%)

1. temperatureunder reflux for 24 h
2. washwashed with diethyl ether
3. extractionextracted with dichloromethane
4. dry with materialThe organic phase was dried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure