Thionyl Chloride → 5-(Chloromethyl)-2-methylpyrimidine

HRID 2200560Notes

Reaction equation

HRID 2200560 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][N:3]=1.S(Cl)([Cl:12])=O>>[Cl:12][CH2:8][C:5]1[CH:4]=[N:3][C:2]([CH3:1])=[N:7][CH:6]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 14686706(2-Methylpyrimidin-5-yl)methanol

Product 1

HCID 146866995-(Chloromethyl)-2-methylpyrimidine

Procedure

A solution of (2-methylpyrimidin-5-yl)methanol (95 mg, 0.77 mmol) in thionyl chloride (1 mL) was stirred at room temperature for 1 h. The mixture was concentrated to dryness and used without purification. LCMS MH+ 143.

Workup

  1. concentrationThe mixture was concentrated to dryness
  2. customused without purification

Sources & evidence

ORD record
ord-2a2b5487c26648388f8b0c144ea6dbcf
Source dataset
uspto-grants-2016_06
Patent number
US09359359B2

Reaction notes

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