HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-(Chloromethyl)-2-methylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-Methylpyrimidin-5-yl)methanol | HCID 14686706 | — |
| Product | 5-(Chloromethyl)-2-methylpyrimidine | HCID 14686699 | — |
Reaction Steps
A solution of (2-methylpyrimidin-5-yl)methanol (95 mg, 0.77 mmol) in thionyl chloride (1 mL) was stirred at room temperature for 1 h. The mixture was concentrated to dryness and used without purification. LCMS MH+ 143.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359359B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-2a2b5487c26648388f8b0c144ea6dbcf |
| Source note | uspto-grants-2016_06 |