HCID 90440991, compound → HCID 90403348, compound

HRID 2200595Notes

Reaction equation

HRID 2200595 reaction equation
[CH3:1][C:2]1[S:6][C:5](/[CH:7]=[CH:8]/[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][CH:3]=1>CO.[Pd]>[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][CH:3]=1

Participants

4

Reactant 1

HCID 90440991HCID 90440991, compound

Product 1

HCID 90403348HCID 90403348, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (E)-ethyl 3-(5-methylthiazol-2-yl)acrylate (200 mg, 1.01 mmol,) in methanol (5 mL) was added 5% Pd/C (20 mg). The reaction was purged with nitrogen and then hydrogen and then was stirred under a hydrogen atmosphere (balloon). The reaction was filtered. The filtrate was concentrated to give ethyl 3-(5-methylthiazol-2-yl)propanoate (200 mg, 99% yield) as a light yellow oil. LCMS retention time 1.33 min; LCMS MH+ 200.

Workup

  1. customThe reaction was purged with nitrogen
  2. filtrationThe reaction was filtered
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-a5163f2461d94ddd90b36bb88ec614c4
Source dataset
uspto-grants-2016_06
Patent number
US09359359B2

Reaction notes

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