反应详情

To a solution of ethyl 4-bromobutanoate (2 g, 10.26 mmol) in acetone (20 mL) was added 3-(trifluoromethoxy)phenol (1.52 g, 8.54 mmol), followed by potassium carbonate (3.5 g, 25.36 mmol). The reaction was stirred at room temperature overnight. The mixture was partitioned between DCM and water. The organic phase was washed with brine, dried over sodium sulfate, and concentrated to give a crude product which was purified by silica gel chromatography eluting with petroleum/ethyl acetate (10:1 to 5:1) to give ethyl 3-(3-(trifluoromethoxy)phenoxy)propanoate (2.3 g, 92.1% yield) as a colorless oil.

1. customThe mixture was partitioned between DCM and water
2. washThe organic phase was washed with brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. customto give a crude product which
6. customwas purified by silica gel chromatography
7. washeluting with petroleum/ethyl acetate (10:1 to 5:1)