Hydrochloric Acid → HCID 178479268, compound

HRID 2200765Notes

Reaction equation

HRID 2200765 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[N:4][C:3]=1[NH:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11][CH2:10]1>>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[N:4][C:3]=1[NH:8][C@H:9]1[CH2:14][CH2:13][C@@H:12]([NH2:15])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178454024HCID 178454024, compound

Product 1

HCID 178479268HCID 178479268, compound

Procedure

As shown in step 5-ii of Scheme 5, HCl (3 mL, 4M in THF, 12 mmol) was added to compound 1010. The mixture was stirred for 30 min and concentrated under reduced pressure to produce (cis)-N1-(pyrimidin-2-yl)cyclohexane-1,4-diamine hydrochloride (compound 1011). This material was used in subsequent reactions as is without further purification.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-71b75e88e68f4ddd8e4c6f9c3ffd797d
Source dataset
uspto-grants-2016_06
Patent number
US09359380B2

Reaction notes

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