Hydrochloric Acid → HCID 71257331, compound

Participants

Reaction Steps

6-(1,4-Dioxaspiro[4.5]dec-8-yloxy)-2-(trifluoromethyl)pyrimidine-4-carboxylic acid (0.50 g, 1.4 mmol) was dissolved in acetone (12.8 mL) To this solution was added a solution of 12.0 M hydrogen chloride in water (1.5 mL, 18 mmol) and stirred at RT for 16 hours at which time LCMS showed the reaction was compete. The reaction mixture was extracted with EtOAc and was evaporated to give the product. The crude product was used in the next step. MS (ES): 305(M+1).

Provenance & Evidence