Hydrochloric Acid → HCID 71257331, compound

HRID 2200803Notes

Reaction equation

HRID 2200803 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([O:11][C:12]3[N:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[N:15]=[C:14]([C:22]([OH:24])=[O:23])[CH:13]=3)[CH2:7][CH2:6]2)[O:4]CC1.Cl.O>CC(C)=O>[O:4]=[C:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[N:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[N:15]=[C:14]([C:22]([OH:24])=[O:23])[CH:13]=2)[CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 71257503HCID 71257503, compound

Product 1

HCID 71257331HCID 71257331, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

6-(1,4-Dioxaspiro[4.5]dec-8-yloxy)-2-(trifluoromethyl)pyrimidine-4-carboxylic acid (0.50 g, 1.4 mmol) was dissolved in acetone (12.8 mL) To this solution was added a solution of 12.0 M hydrogen chloride in water (1.5 mL, 18 mmol) and stirred at RT for 16 hours at which time LCMS showed the reaction was compete. The reaction mixture was extracted with EtOAc and was evaporated to give the product. The crude product was used in the next step. MS (ES): 305(M+1).

Workup

  1. extractionThe reaction mixture was extracted with EtOAc
  2. customwas evaporated
  3. customto give the product

Sources & evidence

ORD record
ord-0796345002a145de822abd89c59b4f40
Source dataset
uspto-grants-2016_06
Patent number
US09359358B2

Reaction notes

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