Hydrogen Peroxide → Glyphosate

HRID 2200828Notes

Reaction equation

HRID 2200828 reaction equation
[P:1]([CH2:5][N:6](CC(O)=O)[CH2:7][C:8]([OH:10])=[O:9])([OH:4])([OH:3])=[O:2].OO>O>[P:1]([CH2:5][NH:6][CH2:7][C:8]([OH:10])=[O:9])([OH:4])([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 80092N-(Carboxymethyl)-N-(phosphonomethyl)glycine

Product 1

HCID 3496Glyphosate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

To 100 mL of water, 5 g of an activated carbon shown in Table 1 and 20.0 g of N-(phosphonomethyl)iminodiacetic acid were added. Into the mixture, 20.0 g of a hydrogen peroxide aqueous solution having a concentration of 30% by mass was added dropwise over 3 hours at 65° C. under stirring while maintaining the temperature of 65° C. After the completion of the dropping, the resulting mixture was maintained for 1 hour, and N-(phosphonomethyl)glycine was then isolated as a crystal. The isolated crystal was quantitatively determined by a high-speed liquid chromatography, and the weight yield and purity were measured.

Workup

  1. additionwere added
  2. additionwas added dropwise over 3 hours at 65° C.
  3. temperatureAfter the completion of the dropping, the resulting mixture was maintained for 1 hour

Sources & evidence

ORD record
ord-dc76c83d11244e558cca8411d211a3d7
Source dataset
uspto-grants-2016_06
Patent number
US09359390B2

Reaction notes

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