反应详情

In DCM (20 mL) was dissolved 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio) pyrimidine-5-carboxylic acid (200 mg, 0.59 mmol). The solution was cooled in an ice bath and m-CPBA (101 mg, 0.59 mmol) was added. The reaction was conducted at ambient temperature for 5 h, followed by addition of water and extraction with DCM. The organic phase was dried and concentrated to give a solid which was used in the subsequent procedure without further purification.

1. temperatureThe solution was cooled in an ice bath
2. customThe organic phase was dried
3. concentrationconcentrated
4. customto give a solid which
5. customwas used in the subsequent procedure without further purification