Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfanyl)pyrimidine-5-carboxylate → HCID 117622625, compound

HRID 2200899Notes

Reaction equation

HRID 2200899 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[CH2:5][NH:6][C:7]1[C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][N:10]=[C:9]([N:18]2[CH2:24][CH2:23][C:20]3([CH2:22][CH2:21]3)[CH2:19]2)[N:8]=1.ClC1C=C(C=CC=1OC)CNC1C(C(OCC)=O)=CN=C(SC)N=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[CH2:5][NH:6][C:7]1[C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=[C:9]([N:18]2[CH2:24][CH2:23][C:20]3([CH2:21][CH2:22]3)[CH2:19]2)[N:8]=1

Participants

3

Reactant 2

HCID 22025927Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfanyl)pyrimidine-5-carboxylateHCID 117622626HCID 117622626, compound

Product 1

HCID 117622625HCID 117622625, compoundYield 54%

Procedure

The procedures were analogous to Example 1(2). Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(5-azaspiro[2.4]heptan-5-yl)pyrimidine-5-carboxylate (3.4 g, 8.17 mmol) was used in step 2 instead of ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate. Yield: 54%.

Sources & evidence

ORD record
ord-d8905dcccd924b2293092206cd0909ec
Source dataset
uspto-grants-2016_06
Patent number
US09359371B2

Reaction notes

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