反应详情

In DCM (50 mL) was dissolved ethyl 4-((3-fluoro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate (2.2 g, 6.3 mmol). m-CPBA (3-chloroperbenzoic acid, 1.1 g, 6.4 mmol) was added. The reaction was conducted at ambient temperature for 30 min. The reaction mixture was washed with water. The organic phase was dried over sodium sulfate and concentrated to give ethyl 4-((3-fluoro-4-methoxybenzyl)amino)-2-(methylsulfinyl)pyrimidine-5-carboxylate. The product was used in the subsequent procedure without further purification.

1. washThe reaction mixture was washed with water
2. dry with materialThe organic phase was dried over sodium sulfate
3. concentrationconcentrated