Hydrochloric Acid → (R)-2-amino-3-methoxypropanamide hydrochloride

HRID 2201082Notes

Reaction equation

HRID 2201082 reaction equation
[NH2:1][C:2](=[O:15])[C@H:3]([NH:7]C(=O)OC(C)(C)C)[CH2:4][O:5][CH3:6].[ClH:16]>O1CCOCC1>[ClH:16].[NH2:7][C@H:3]([CH2:4][O:5][CH3:6])[C:2]([NH2:1])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86666155(R)-tert-butyl 1-amino-3-methoxy-1-oxopropan-2-ylcarbamate

Product 1

HCID 86666156(R)-2-amino-3-methoxypropanamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of (R)-tert-butyl 1-amino-3-methoxy-1-oxopropan-2-ylcarbamate (342 mg, 1.57 mmol) in 4N HCl in dioxane (5 mL) was stirred at room temperature for 18 h. It was then concentrated in vacuo to give (R)-2-amino-3-methoxypropanamide hydrochloride (260 mg).

Workup

  1. concentrationIt was then concentrated in vacuo

Sources & evidence

ORD record
ord-67c2140f2652451ca2a6b22f652a2d43
Source dataset
uspto-grants-2016_06
Patent number
US09359375B2

Reaction notes

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