HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-2-amino-2-cyclopropylacetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-tert-butyl 2-amino-1-cyclopropyl-2-oxoethylcarbamate | HCID 67776181 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-2-amino-2-cyclopropylacetamide hydrochloride | HCID 67508384 | — |
Reaction Steps
A solution of (R)-tert-butyl 2-amino-1-cyclopropyl-2-oxoethylcarbamate (300 mg, 1.40 mmol) in 4N HCl in dioxane (8 mL) was stirred at room temperature for 20 min. It was then concentrated in vacuo to give (R)-2-amino-2-cyclopropylacetamide hydrochloride (225 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359375B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-d47152a3947f4140940e6fe980514e92 |
| Source note | uspto-grants-2016_06 |