Hydrochloric Acid → (R)-2-amino-2-cyclopropylacetamide hydrochloride

HRID 2201101Notes

Reaction equation

HRID 2201101 reaction equation
[NH2:1][C:2](=[O:15])[C@H:3]([NH:7]C(=O)OC(C)(C)C)[CH:4]1[CH2:6][CH2:5]1.[ClH:16]>O1CCOCC1>[ClH:16].[NH2:7][C@H:3]([CH:4]1[CH2:6][CH2:5]1)[C:2]([NH2:1])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67776181(R)-tert-butyl 2-amino-1-cyclopropyl-2-oxoethylcarbamate

Product 1

HCID 67508384(R)-2-amino-2-cyclopropylacetamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of (R)-tert-butyl 2-amino-1-cyclopropyl-2-oxoethylcarbamate (300 mg, 1.40 mmol) in 4N HCl in dioxane (8 mL) was stirred at room temperature for 20 min. It was then concentrated in vacuo to give (R)-2-amino-2-cyclopropylacetamide hydrochloride (225 mg).

Workup

  1. concentrationIt was then concentrated in vacuo

Sources & evidence

ORD record
ord-d47152a3947f4140940e6fe980514e92
Source dataset
uspto-grants-2016_06
Patent number
US09359375B2

Reaction notes

Loading…