Hydrochloric Acid → (R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride

HRID 2201113Notes

Reaction equation

[NH2:1][C:2](=[O:19])[C@H:3]([NH:11]C(=O)OC(C)(C)C)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.[ClH:20]>>[ClH:20].[NH2:11][C@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)[C:2]([NH2:1])=[O:19]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 67774698(R)-tert-butyl 1-amino-1-oxo-3-(pyridin-2-yl)propan-2-ylcarbamate

Product 1

HCID 67508637(R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride

Procedure

A solution of (R)-tert-butyl 1-amino-1-oxo-3-(pyridin-2-yl)propan-2-ylcarbamate (280 mg, 0.739 mmol) in aq. 6N HCl (8 mL) was stirred at room temperature for 2 h. It was then concentrated in vacuo to give (R)-2-amino-3-(pyridin-2-yl)propanamide hydrochloride (170 mg).

Workup

concentrationIt was then concentrated in vacuo

Sources & evidence

ORD record: ord-2b99ad537e474ee690501f943e2dd03c
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09359375B2

Reaction notes

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