4-Amino-2-chlorophenol → HCID 68756416, compound

HRID 220127Notes

Reaction equation

HRID 220127 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[OH:21])[NH2:17]>>[ClH:1].[Cl:13][C:14]1[CH:15]=[C:16]([NH:17][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:18]=[CH:19][C:20]=1[OH:21]

Participants

3

Reactant 2

HCID 775784-Amino-2-chlorophenolHCID 111738094-Chloro-6-iodoquinazoline

Product 1

HCID 68756416HCID 68756416, compoundYield 88%

Procedure

According to the same manner as that of the first step of Example 1 and using 20.3 g of 4-chloro-6-iodoquinazoline and 10 g of 3-chloro-4-hydroxyaniline, 4-(3-chloro-4-hydroxyphenylamino)-6-iodoquinazoline hydrochloride (III-4, 26.6 g) was obtained as a yellow solid.

Sources & evidence

ORD record
ord-3b1dfe0909884d00982a1fbe1b0d24e8
Source dataset
uspto-grants-2012_06
Patent number
US08202879B2

Reaction notes

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