HCID 86723531, compound → HCID 86723532, compound

HRID 2201300Notes

Reaction equation

HRID 2201300 reaction equation
[CH3:1][N:2]1[C:7]2=[CH:8][N:9]([CH2:17][CH2:18][CH2:19][C:20](O)=[O:21])[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[C:6]2[C:5](=[O:23])[N:4]([CH3:24])[C:3]1=[O:25]>O>[CH3:1][N:2]1[C:7]2=[C:8]3[N:9]([C:10]([C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=4)=[C:6]2[C:5](=[O:23])[N:4]([CH3:24])[C:3]1=[O:25])[CH2:17][CH2:18][CH2:19][C:20]3=[O:21]

Participants

3

Reactant 1

HCID 86723531HCID 86723531, compound

Product 1

HCID 86723532HCID 86723532, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

4-(1,3-Dimethyl-2,4-dioxo-5-phenyl-1,2,3,4-tetrahydro-pyrrolo[3,4-d]pyrimidin-6-yl)-butyric acid (step 2)(1.3 g, 3.81 mmol) and polyphosphoric acid (10 g, 3.81 mmol) were combined and heated at 80° C. for 1 hour. The reaction mixture was cooled to RT, diluted with water and extracted with chloroform (4×). The combined organic extracts were passed through a hydrophobic frit and evaporated under reduced pressure. The title product was afforded as a pale yellow solid.

Workup

  1. temperatureThe reaction mixture was cooled to RT
  2. extractionextracted with chloroform (4×)
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-9fda9f5faee34218a671a2b56d7b80da
Source dataset
uspto-grants-2016_06
Patent number
US09359381B2

Reaction notes

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