HCID 86723531, compound → HCID 86723532, compound

Participants

Reaction Conditions

Reaction Steps

4-(1,3-Dimethyl-2,4-dioxo-5-phenyl-1,2,3,4-tetrahydro-pyrrolo[3,4-d]pyrimidin-6-yl)-butyric acid (step 2)(1.3 g, 3.81 mmol) and polyphosphoric acid (10 g, 3.81 mmol) were combined and heated at 80° C. for 1 hour. The reaction mixture was cooled to RT, diluted with water and extracted with chloroform (4×). The combined organic extracts were passed through a hydrophobic frit and evaporated under reduced pressure. The title product was afforded as a pale yellow solid.

Provenance & Evidence