HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-fluorobenzene → 5-(3-Fluorophenyl)-1,3,8-trimethyl-8,9-dihydropyrimido[4,5-a]indolizine-2,4,10(1H,3H,7H)-trione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-fluorobenzene | HCID 14082 | — |
| Reactant | Methyl 4-bromobutyrate | HCID 107604 | — |
| Reactant | Methyl 4-bromo-3-methylbutanoate | HCID 14104192 | — |
| Reactant | 3-(1,3-Dimethyl-2,4,10-trioxo-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizin-5-yl)benzonitrile | HCID 86723427 | — |
| Product | 5-(3-Fluorophenyl)-1,3,8-trimethyl-8,9-dihydropyrimido[4,5-a]indolizine-2,4,10(1H,3H,7H)-trione | HCID 86723534 | — |
Reaction Steps
The title compound was prepared analogously to 3-(1,3-dimethyl-2,4,10-trioxo-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizin-5-yl)benzonitrile (Example 9 steps 1-7) by replacing 3-bromobenzonitrile (step 3) with 1-bromo-3-fluorobenzene (commercially available) and methyl 4-bromobutanoate (Step 5) with methyl 4-bromo-3-methylbutanoate (Intermediate T).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359381B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-fd433ea5f5024f5baa9250108018edbd |
| Source note | uspto-grants-2016_06 |