Hydrochloric Acid → HCID 117988971, compound

HRID 2201352Notes

Reaction equation

HRID 2201352 reaction equation
C([O:3][C:4]([N:6]1[C:11]([S:12][CH2:13][CH3:14])=[CH:10][CH:9]=[CH:8][NH:7]1)=[O:5])C.[OH-].[Na+].Cl>CO>[CH2:13]([S:12][C:11]1[N:6]([C:4]([OH:5])=[O:3])[NH:7][CH:8]=[CH:9][CH:10]=1)[CH3:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 117988572HCID 117988572, compound

Product 1

HCID 117988971HCID 117988971, compoundYield 27.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 2.59 g of 3-ethylsulfanylpyridazine-2-carboxylic acid ethyl ester, 5 ml of a 5 M aqueous sodium hydroxide solution, and 8 ml of methanol was stirred at 85° C. for 4 hours. Concentrated hydrochloric acid was poured to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and dried to obtain 612 mg of 3-ethylsulfanylpyridazine-2-carboxylic acid. 3-Ethylsulfanylpyridazine-2-carboxylic acid

Workup

  1. filtrationthe precipitated solid was filtered
  2. washThe resulting solid was washed with water
  3. customdried

Sources & evidence

ORD record
ord-361ab0030a564bf685de1d9fddd7ff2f
Source dataset
uspto-grants-2016_06
Patent number
US09364000B2

Reaction notes

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