Triphenylphosphine → HCID 117988751, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.69 g of 2-ethylsulfanyl-N-(2-hydroxy-5-trifluoromethylpyridin-3-yl) nicotinamide, 0.75 g of bis(2-methoxyethyl) azodicarboxylate (hereinafter referred to as DMEAD), 0.79 g of triphenylphosphine and 7 ml of THF was stirred at 50° C. for 4 hours. A saturated aqueous ammonium chloride solution was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over sodium sulfate, and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.34 g of 2-(2-ethylsulfanylpyridin-3-yl)-6-(trifluoromethyl)oxazolo[5,4-b]pyridine (hereinafter, referred to as Compound of Present Invention 32).

Provenance & Evidence