Ammonium Hydroxide → HCID 178471768, compound

HRID 220139Notes

Reaction equation

HRID 220139 reaction equation
[OH-].[NH4+:2].Cl[C:4]([C:6]1[CH:11]=[CH:10][C:9]([C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1)=[O:5]>>[C:4]([C:6]1[CH:11]=[CH:10][C:9]([C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1)(=[O:5])[NH2:2]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 178471771HCID 178471771, compound

Product 1

HCID 178471768HCID 178471768, compoundYield 100%

Procedure

Ammonium hydroxide (large excess) was added to the product from Example 1C (8.43 g, 27.3 mmol) at room temperature. White solids precipitated out and were collected by filtration and washed with water to afford the title compound (7.9 g, 100%) as a white solid which was taken on to the next step without further purification. MS (DCI) m/z 290.1 [M+H]+.

Workup

  1. customWhite solids precipitated out
  2. filtrationwere collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-0f404371cadd46e7858ead0a2208651b
Source dataset
uspto-grants-2012_06
Patent number
US08202878B2

Reaction notes

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