HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 7-Methoxy-3-(4-(methoxycarbonyl)phenyl)quinoline 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | Methyl 4-(7-methoxyquinolin-3-yl)benzoate | HCID 67974241 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Methoxy-3-(4-(methoxycarbonyl)phenyl)quinoline 1-oxide | HCID 67974256 | 81% |
Reaction Steps
A mixture of methyl 4-(7-methoxyquinolin-3-yl)benzoate (632 mg, 2.16 mmol), m-CPBA (742 mg, 4.31 mmol) and DCM (10 mL) was stirred overnight. Saturated Na2CO3 solution was added and adjusted the pH>7, the organic layer was washed with water (50 mL×2), dried over NaSO4 and evaporated in vacuo to give the crude product as a yellow solid (540 mg, 81.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09364481B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-d3478bec010048f0b887e788e2f3e00a |
| Source note | uspto-grants-2016_06 |