Hydrochloric Acid → HCID 6415827, compound

HRID 2201504Notes

Reaction equation

HRID 2201504 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH2:9]2)=[CH:5][CH:4]=1.[N:12](OCCC(C)C)=[O:13].Cl.C[OH:22]>>[OH:13]/[N:12]=[C:8]1/[C:9](=[O:22])[C:10]2[C:6]([CH2:7]/1)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:11]=2

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 8053Isoamyl NitriteHCID 2281255-Methoxyindan

Product 1

HCID 6415827HCID 6415827, compoundYield 50%

Conditions

Temperature
40 °C

Procedure

6-methoxy-2,3-dihydro-1H-inden-(17.2 g, 106 mmol) was dissolved in methanol (700 mL). The mixture was heated to 40° C., then isoamyl nitrite (30 mL, 220 mmol) and concentrated hydrochloric acid (17 mL) were added. The reaction mixture was stirred at 40° C. for 2 hours. After cooled to room temperature, the precipitate was collected by filtration and dried under high vacuum to obtain product (10.0 g, yield 50%).

Workup

  1. temperatureAfter cooled to room temperature
  2. filtrationthe precipitate was collected by filtration
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-6f9a4cef6b3d48808de7dcdb7a1b9731
Source dataset
uspto-grants-2016_06
Patent number
US09364481B2

Reaction notes

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