反应详情

温度

130 °C

To a solution of 6-bromo-N-(4-chlorobenzyl)-3-methoxypicolinamide (800 mg, 2.25 mmol) in DMF (10 mL) was added lithium chloride (954 mg, 22.5 mmol), and the mixture was heated at 130° C. for 16 h. The mixture was concentrated in vacuo and the residue was suspended in water. Finally, the crude 6-bromo-N-(4-chlorobenzyl)-3-hydroxypicolinamide (700 mg, yield: 91%) was obtained by filtration. 1H-NMR (DMSO-d6, 400 MHz) δ 12.47 (br s, 1H), 9.67 (s, 1H), 7.71 (d, J=8.8 Hz, 1H), 7.34˜7.42 (m, 5H), 4.46 (d, J=6.0 Hz, 2H). MS (M+H)+: 341/343.

1. concentrationThe mixture was concentrated in vacuo